PenethaOne
Contains penethamate hydriodide for intramuscular injection in cattle
Features
-
Designated as 'green light' antibiotic in NZ
-
Injectable antibiotic suitable for treating clinical mastitis
-
Contains penethamate hydroiodide - a precursor of benzylpenicillin
-
Front-line treatment for the most common mastitis bacteria in NZ cows and heifers, including Streptococci and Staphylococci
-
Suitable treatment for multi-quarter mastitis infections in cows and heifers
-
Suitable treatment where cow behavioural issues such as kicking makes it difficult to infuse intramammary products
-
PenethaOne 15MIU treats 1 cow per bottle
Pack Sizes
PenethaOne is available as individual 5MIU treatments or in two 5-cow pack options:
- 5MIU single pack: one individual treatment, with diluent supplied
- Multipack: 15 × 5MIU vials — 15 treatments, enough to treat 5 cows
- 15MIU 5 Cow Pack: 5 × 15MIU vials — one vial per cow, enough to treat 5 cows
Diluent is supplied with all pack sizes.
Action
Penethamate is able to cross from the blood stream into milk, where penethamate becomes 'trapped'. This increases effectiveness of penethamate for mastitis treatment.
Indication
PenethaOne is indicated for the treatment and control of infections caused by penicillin-sensitive Gram-positive bacteria that cause mastitis, metritis, respiratory infections and footrot in cattle.
Dosage
The volume (mL) you need to administer depends on which PenethaOne pack you are using. Check your vial before dosing.
Which PenethaOne Pack are you using?
| 15MIU 5 Cow Pack | 5MIU Multipack | |
| Check the Vial | 15MIU | 5MIU |
| Pack Contains | 5 x 15 MIU vials + 5 x 36mL Diluent | 15 x 5 MIU vials + 15 x 18mL Diluent |
| 5MIU Dose Volume | 15mL | 20mL |
Using the 15MIU 5 Cow Pack
Check your vial says 15MIU.
Reconstitute the powder contained in the vial by adding all the contents (36mL) of the diluent supplied. Shake well after reconstitution. Each 15mL of reconstituted suspension contains 5 MIU of penethamate.
1. Cattle: 5 MIU (15 mL) once daily (equivalent to 10,000 - 15,000 IU/kg bodyweight/ day). Repeat dose daily for 1 – 5 days.
2. For mastitis in lactating dairy cattle: Use the above dosing or alternatively give 10 MIU (30 mL) on Day one, followed by 5 MIU (15 mL) on Day two.
A maximum dosage volume of 20mL per injection site should be administered.
Using the 5MIU Multipack
Check your vial says 5MIU.
Reconstitute the powder contained in the vial by adding all the contents (18mL) of the diluent supplied. Shake well after reconstitution. Each 20mL of reconstituted suspension contains 5 MIU of penethamate.
1. Cattle: 5 MIU (20mL) once daily (equivalent to 10,000 - 15,000 IU/kg bodyweight/day). Repeat dose daily for 1 – 5 days.
2. For mastitis in lactating dairy cattle: Use the above dosing or alternatively give 10 MIU (40mL) on Day one, followed by 5 MIU (20mL) on Day two.
A maximum dosage volume of 20mL per injection site should be administered.
Withholding times
Withholding Times:
Meat: 7 days
Milk: 48 hours (5 MIU dose); 60 hours (10 MIU dose plus 5 MIU).
Other
Store below 25°C
The reconstituted aqueous suspension is stable for 12 hours at 25°C (room temperature) or for 7 days when stored between 2 – 8°C (refrigerated).
ACVM Registration Number A11828. Restricted Veterinary Medicine. Available only under Veterinary Authorisation.