Cyclase (PG) Injection

Description

Cloprostenol (as sodium) 250μg/mL in an aqueous injection for cattle, horses and pigs

Pack Sizes

Available in 100mL (50 dose) plastic multi-dose vials

Action

Cyclase is a potent luteolytic agent and a synthetic analogue of prostaglandin F2α (PGF2α). PGF2α causes the functional and morphological regression of the corpus luteum, with a resultant rapid decline in progesterone production. Luteolysis is followed by ovarian follicle development, oestrus, and ovulation. Oestrus occurs 2 to 5 days after luteolysis in the cow and mare. In the cow and the mare, a refractory period of 4-5 days occurs after ovulation during which animals are insensitive to the luteolytic effect of prostaglandins. PGF2α has a direct stimulant effect on smooth muscle causing contraction of the uterus and relaxation of the cervix.

Indication

For luteolysis of functional corpora lutea in cows, pigs and horses. Manipulation of oestrous cycles, treatment of retained foetal membranes, pyometra or chronic endometritis and induction of abortion and parturition in cows.
Complements use of the DIB-V (A10319) and Dib-h (A10832) progesterone inserts and Gonasyn (A10642) in DIB-Synch oestrus synchrony programs and also Novormon (A10641) in DIB-Synch Plus programs. Cyclase 100mL can be used as the diluent for the freeze dried Novormon 20,000IU pack size.

Dosage

CATTLE:
Single or repeated 2mL doses (500μg cloprostenol) administered by i/m or s/c injection into the anterior half of the neck.
Oestrus synchronisation and ovulation: Animals not showing heat should receive one 2mL dose (500μg cloprostenol) or two 2mL doses (500μg cloprostenol) 11-14 days apart (heifers typically 14 days). Heat is displayed 2 to 4 days after the last dose.
Controlled breeding programs: Administer one 2mL dose (500μg cloprostenol). Use as part of a DIB-Synch controlled breeding program for oestrus synchronisation to cause luteolysis. Follow the directions outlined in the program documentation.
Treatment of anoestrus: Administer one 2mL dose (500μg cloprostenol). Use as part of a DIB-Synch controlled breeding program for the treatment of postpartum anoestrus to cause luteolysis. Follow the directions outlined in the program documentation.
Use early in postpartum period to improve reproductive efficiency one or two 2mL doses (500μg cloprostenol) administered between 12-40 days postpartum will improve uterine involution, thereby reducing the likelihood of the occurrence of infections.
Termination of early pregnancy: Terminates pregnancy from one week after conception until day 150 of gestation. Prior to 100 days of gestation, induces abortion rapidly and efficiently. Most cows will abort 3 - 5 days after treatment. Between days 100 and 150 of gestation results are less reliable due to the presence of significant concentrations of progesterone in the plasma.
Removal of mummified foetus: Induction of luteolysis will result in the expulsion of the mummified foetus.
Induction of parturition: One 2mL dose (500μg cloprostenol) administered to cows after day 270 of gestation will usually induce calving within 48 hours.
Retention of foetal membranes and / or chronic purulent endometritis (pyometra): Treat with a single 2mL dose (500μg cloprostenol).
Luteal cysts: Ovarian cysts may be associated with persistent luteal tissue: treatment with cloprostenol may stimulate the cow to return to normal oestrus.
Horses:
Doses of 0.5 - 1mL (125 - 250μg cloprostenol) for mares up to 400kg b.w. and 1-2mL (250-500μg cloprostenol) for mares weighing over 400kg b.w, administered by i/m injection into the anterior half of the neck.
Anoestrus treatment: A single 0.8 - 2mL dose (200 - 500μg cloprostenol) may be used to treat many causes of anoestrus in mares such as persistent dioestrus, pseudopregnancy and early embryo death (up to 100 days).
Handling during oestrus: One or two 1mL doses (250μg cloprostenol) at a 14 day interval.
Induction of abortion: Administer 1mL (250μg cloprostenol) prior to day 35 of gestation.
Pigs:
A single 0.7mL dose (175μg cloprostenol) administered by i/m injection into the anterior half of the neck.
Induction of parturition: One 0.7mL dose (175μg cloprostenol) administered within 3 days of expected parturition induces parturition 24 hours after treatment.

Contraindication

Do not use in pregnant animals unless the objective is to terminate pregnancy. Do not administer by intravenous injection. Horses: Do not administer to mares suffering disorders of the gastrointestinal or respiratory tract.

Withholding times

Nil

Special Precautions

Cloprostenol may affect fertility and the foetus of pregnant women. May cause respiratory problems in high doses. Prostaglandins may cause bronchospasm. Cloprostenol can be absorbed through the skin. Avoid skin contact, especially in women of child bearing age.

Other

Store below 25°C away from direct light. Use within 30 days of opening the pack.
ACVM Registration Number A10490. Restricted Veterinary Medicine. Available only under Veterinary Authorisation.

Video Links

Associated Documents

Cyclase NZ Label Cyclase SDS Why Wait Program Cyclase and Novormon mixing instructions Tech Bulletin R12 - Cyclase as a Diluent for Novormon Tech Bulletin R14 - Evaluation of prostaglandin dose in non-cycling cows in NZ Tech Bulletin R16 - Evaluation of prostaglandin dose in NZ cycling cows